2,849 research outputs found
Recent advance in direct sp3 carbon-hydrogen bond functionalizations
Direct and selective carbon-hydrogen bond functionalization has attracted enormous attention because it provides more efficient strategies for preparing valuable functional molecules from easily available substrates. Significant and exciting developments in functionalization of un-activation Csp3-H bonds have continuously been made over the past few decades. This review mainly summarizes recent advances on direct Csp3-H bond functionalization for the formation of C-C and C-heteroatom bond under transition-metal-catalysed and metal-free conditions
Generalized quaternion groups with the -DCI property
A Cayley digraph Cay(G,S) of a finite group with respect to a subset
of is said to be a CI-digraph if for every Cayley digraph Cay(G,T)
isomorphic to Cay(G,S), there exists an automorphism of such that
. A finite group is said to have the -DCI property for some
positive integer if all -valent Cayley digraphs of are CI-digraphs,
and is said to be a DCI-group if has the -DCI property for all . Let be a generalized quaternion group of order
with an integer , and let have the -DCI
property for some . It is shown in this paper that is
odd, and is not divisible by for any prime . Furthermore,
if is a power of a prime , then has the -DCI
property if and only if is odd, and either or .Comment: 1
Diagnostic performance of microRNA-133a in acute myocardial infarction: A meta-analysis
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 Background: The aim of this study was to evaluate the diagnostic performance of microRNA-133a in the diagnosis of acute myocardial infarction (AMI).
Methods: Major databases including PubMed, Embase and the Cochrane Library were searched for case-controlled studies comparing AMI and non-AMI patients. The outcome was evaluated by the relative expression of microRNA-133a in plasma or serum. The Mantel-Haenszel odds ratio (OR) was calculated using a fixed-effects model meta-analysis for the outcome. The primary outcomes of interest were pooled sensitivity, specificity and diagnostic accuracy of microRNA-133a for AMI.
Results: Out of 137 identified related articles, 10 were found to conform with the inclusion and exÂclusion criteria of the study. The 10 case-controlled studies contained complete data for 1,074 patients (with no restrictions of race, age or sex), and a database containing 137 patients from the registry of each study. In addition to low heterogeneity, a statistically significant increase was found in overall microRNA-133a expression between AMI vs. non-AMI; the pooled OR was 22.84 (95% confidence interval [CI] 13.87–37.63), sensitivity was 0.84 (95% CI 0.75–0.90), specificity was 0.82 (95% CI 0.74–0.89) and area under curve (AUC) was 0.90 (95% CI 0.87–0.92).
Conclusions: Based on the meta-analysis of ten case-controlled studies including 1,074 patients,it was found that the level of microRNA-133a in blood serum or plasma maybe used as a diagnostic biomarker of AMI
2-(4-ChloroÂphenÂyl)-5-(3,4-dimethoxyÂphenethÂyl)-6,7-dihydroÂpyrazolo[1,5-a]pyrazin-4(5H)-one
In the title compound, C22H22ClN3O3, the dihedral angles between the planes of the benzene rings and the pyrazole ring are 16.05 (10) and 84.84 (10)°. The conformation of the six-membered heterocyclic ring is close to a screw-boat. The crystal packing is stabilized by weak interÂmolecular C—H⋯O interÂactions and is also consolidated by C—H⋯π interÂactions
Triaqua-1κ3 O-μ-cyanido-1:2κ2 N:C-pentaÂcyanido-2κ5 C-tetraÂkisÂ(dimethylÂformamide-1κO)-1-holmium(III)-2-iron(III) monohydrate
In the bimetallic cyanide-bridged title complex, [Fe0.98HoRu0.02(CN)6(C3H7NO)4(H2O)3]·H2O, the HoIII ion is in a slightly distorted square-antiÂprismatic arrangement formed by seven O atoms from four dimethylÂformamide (DMF) molÂecules and three water molÂecules, and one N atom from a bridging cyanide group connected with the FeIII atom which is octaÂhedrally coordinated by six cyanide groups. In the crystal, molÂecules are held together through O—H⋯N and O—H⋯O hydrogen-bonding interÂactions to form a three-dimensional framework. Elemental analysis of one of the precursors and the crystal shows that there is a slight contamination of Fe by Ru. The Fe site displays, therefore, small substitutional disorder with site-occupancy factors Fe/Ru = 0.98:0.02. The two methyl groups of two dimethylÂformamide ligands are positionally disordered with site-occupancy factors of 0.44 (3):0.56 (3) and 0.44 (3):0.56 (3)
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